This personal account focuses on synthesis of polyhydroxylated piperidines, a subset of
compounds within the iminosugar family. Cyclisations to form the piperidine ring include …

Imino sugars, despite being firstly studied as inhibitors more than forty years ago, are still a
relevant target in Medicinal and Bioorganic Chemistry, because of their numerous and …

Two new polyhydroxylated nortropane analogues closely related with Calystegines have
been prepared in excellent chemical yields and complete selectivity. A synthetic strategy …

The synthesis, conformational study and inhibitory properties of diverse indolizidine and
quinolizidine iminocyclitols are described. The compounds were chemo-enzymatically …

Only few naturally occurring pyrrolizidine imino sugars possess a geminal‐
hydroxyhydroxymethyl group. In search for more potent and selective inhibitors of …

The scope and limitations of the simple synthesis of functionalized quinolizidin-4-ones by
chemoselective N-alkenylation of NH pyridin-2 (1H)-ones (2-pyridones), regioselective …

ABSTRACT A stereodivergent approach for producing piperidine iminosugars has been
developed employing a common optically active precursor. The key steps of the synthetic …

In this study, a virtual screening procedure was applied to identify new potential nt-MGAM
inhibitors as a possible medication for type 2 diabetes. To this aim, a series of salacinol …

N (Silylmethyl)amines, amides, and amino acids: biological activity and prospects in drug
synthesis Page 1 Russian Chemical Bulletin, International Edition, Vol. 60, No. 4, pp. 615—632 …

The evolution of chemistry associated with the photoinduced electron transfer (PET)-
generated?-trimethylsilylmethylamine radical cation cyclization to a tethered olefin to …