The reproducibility of experiments has been a long standing impediment for further scientific
progress. Computational methods have been instrumental in drug discovery efforts owing to …

In recent years, the advent of new experimental methodologies for studying the high
complexity of the human genome and proteome has led to the generation of an increasing …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the curation and archival …

ChEMBL is a large, open-access bioactivity database (https://www. ebi. ac. uk/chembl),
previously described in the 2012, 2014 and 2017 Nucleic Acids Research Database Issues …

The cyclooxygenase-2 receptor is a therapeutic target for planning potential drugs with anti-
inflammatory activity. The selective cyclooxygenase-2 (COX-2) inhibitor rofecoxib was …

The study aims to promote network toxicology strategy to efficiently investigate the putative
toxicity and underlying molecular mechanisms of environmental pollutants through an …

Each year, publicly available databases are updated with new compounds from different
research institutions. Positive experimental outcomes are more likely to be reported; …

The increasing use of information technology in the discovery of new molecular entities
encourages the use of modern molecular-modeling tools to help teach important concepts of …

The coronavirus disease 2019 pandemic accelerated drug/vaccine development processes,
integrating scientists all over the globe to create therapeutic alternatives against this virus. In …

The era of big data is surrounded by plenty of challenges, concerning aspects related to
data quality, data management, and data analysis. Plenty of these challenges are met in …