Chronic inflammation is characterized by longstanding microglial activation followed by
sustained release of inflammatory mediators, which aid in enhanced nitrosative and …

Mitochondrial dysfunction plausibly underlies the aging-associated brain degeneration.
Mitochondria play a pivotal role in cellular bioenergetics and cell-survival. Oxidative stress …

In general, proteins can only execute their various biological functions when they are
appropriately folded. Their amino acid sequence encodes the relevant information required …

The brain of patients with Alzheimer disease (AD) showed the evidence of reduced
expression of insulin and neuronal insulin receptors, as compared with those of age …

Objective: Alzheimer's disease (AD) is a devastating neurodegenerative disorder,
characterized by the extracellular accumulations of amyloid beta (Aβ) as senile plaques and …

Background: Alzheimer disease (AD) typically affects behavior, memory and thinking. The
change in brain have been reported to begin approx. 10-20 years before the appearance of …

Nanomaterials are utilized in a wide array of end user products such as pharmaceuticals,
electronics, clothes and cosmetic products. Due to its size (< 100 nm), nanoparticles have …

Neurodegenerative disorders (NDDs) are characterized by the progressive loss of structure
or neuron function, often associated with neuronal death. Treatments for neurodegenerative …

The two most common forms of dementia are Alzheimer's disease (AD) followed by vascular
dementia (VaD), together accounting for a whopping 60-80% of total dementia cases …

Recent studies have led to an increased interest to categorize small molecular inhibitors of
protein fibrillation. In this study, we used spectroscopy, microscopy and gel electrophoresis …