Since the late 1990s, there has been a steady decline in cancer-related mortality, in part
related to the introduction of so-called targeted therapies. Intended to interfere with a specific …

Type I interferons, which make up the first cytokine family to be described and are the
essential mediators of antivirus host defense, have emerged as central elements in the …

Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic
lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute …

Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation
activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We …

Rationale: Neutrophil extracellular trap (NET) formation promotes vascular damage,
thrombosis, and activation of interferon-α–producing plasmacytoid dendritic cells in …

Objective Dysregulation of innate and adaptive immune responses contributes to the
pathogenesis of systemic lupus erythematosus (SLE) and its associated premature vascular …

The etiopathogenesis of systemic lupus erythematosus (SLE), a clinically heterogeneous
multisystemic syndrome that derives its name from the initial characterization of facial …

BACKGROUND. Systemic lupus erythematosus (SLE) is associated with enhanced risk of
atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS) …

Objective To evaluate the specificity of expression patterns of cell‐free circulating
microRNAs (miRNAs) in systemic lupus erythematosus (SLE). Methods Total RNA was …

Systemic Lupus Erythematosus (SLE) is associated with increased risk for accelerated
atherosclerosis and cardiovascular (CV) events including coronary heart disease …