A review on the safety of using JAK inhibitors in dermatology: clinical and laboratory monitoring

C Samuel, H Cornman, A Kambala… - Dermatology and Therapy, 2023 - Springer
Janus kinase (JAK) inhibitors are disease-modifying agents with efficacy in treating a
spectrum of burdensome dermatologic conditions. The US Food and Drug Administration …

A review of safety outcomes from clinical trials of baricitinib in rheumatology, dermatology and COVID-19

T Bieber, E Feist, AD Irvine, M Harigai, E Haladyj… - Advances in …, 2022 - Springer
Baricitinib is an oral, selective inhibitor of Janus kinase (JAK) 1/JAK2 that transiently and
reversibly inhibits many proinflammatory cytokines. This mechanism is a key mediator in a …

Expert consensus on the systemic treatment of atopic dermatitis in special populations

DN Adam, MJ Gooderham, JR Beecker… - Journal of the …, 2023 - Wiley Online Library
With the increasing number of options for the treatment of moderate‐to‐severe atopic
dermatitis, clinicians need guidance on a practical approach to selecting a systemic agent …

Baricitinib safety for events of special interest in populations at risk: analysis from randomised trial data across rheumatologic and dermatologic indications

PC Taylor, T Bieber, R Alten, T Witte, J Galloway… - Advances in …, 2023 - Springer
Abstract Introduction Baricitinib, a Janus kinase (JAK) 1/2 inhibitor, is an approved treatment
for rheumatoid arthritis (RA), atopic dermatitis (AD), and alopecia areata (AA). Further …

Malignancy risk in patients with atopic dermatitis: a population-based cohort study

J Wan, DB Shin, MN Syed, K Abuabara… - British Journal of …, 2023 - academic.oup.com
Background Atopic dermatitis (AD) is associated with immunological dysfunction, which may
influence cancer development. Previous studies of AD and cancer demonstrate inconsistent …

Dupilumab-associated lymphoid reactions in patients with atopic dermatitis

CM Boesjes, LF van der Gang, DS Bakker… - JAMA …, 2023 - jamanetwork.com
Importance Since the increased use of dupilumab for atopic dermatitis (AD) in daily practice,
several cases have been reported on the development of cutaneous T-cell lymphomas …

Safety of baricitinib for the treatment of atopic dermatitis over a median of 1.6 years and up to 3.9 years of treatment: an updated integrated analysis of eight clinical …

T Bieber, N Katoh, EL Simpson… - Journal of …, 2023 - Taylor & Francis
Abstract Background Baricitinib, a selective Janus kinase (JAK) 1/JAK2 inhibitor, is
approved for treatment of moderate-to-severe atopic dermatitis (AD) in adults. Objectives We …

The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update

T Çetinarslan, L Kümper… - Frontiers in Molecular …, 2023 - frontiersin.org
Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with
various clinical presentations and combinations of symptoms. The pathophysiology of AD is …

[HTML][HTML] Effect of disease severity on comorbid conditions in atopic dermatitis: nationwide registry-based investigation in Finnish adults

V Kiiski, L Ukkola-Vuoti, J Vikkula, M Ranta… - Acta Dermato …, 2023 - ncbi.nlm.nih.gov
The majority of registry studies on atopic dermatitis include only patients and diagnoses from
specialized healthcare. The aim of this retrospective, real-world cohort study was to evaluate …

Safety and danger considerations of novel treatments for atopic dermatitis in context of primary cutaneous lymphomas

K Kołkowski, M Trzeciak… - International Journal of …, 2021 - mdpi.com
The impact of new and emerging therapies on the microenvironment of primary cutaneous
lymphomas (PCLs) has been recently raised in the literature. Concomitantly, novel …