Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are the key
histological findings in patients with idiopathic nephrotic syndrome (INS). Although MCD and …

The pathogenesis of minimal change disease (MCD), considered to be the simplest form of
nephrotic syndrome, has been one of the major unsolved mysteries in kidney disease. In this …

The main manifestations of nephrotic syndrome include proteinuria, hypoalbuminemia,
edema, hyperlipidemia and lipiduria. Common causes of nephrotic syndrome are diabetic …

Rapidly progressive glomerulonephritis (RPGN) is a life-threatening clinical syndrome and a
morphological manifestation of severe glomerular injury that is marked by a proliferative …

The molecular link between proteinuria and hyperlipidemia in nephrotic syndrome is not
known. We show in the present study that plasma angiopoietin-like 4 (Angptl4) links …

Neph1-deficient mice develop nephrotic syndrome at birth, indicating the importance of this
protein in the development of a normal glomerular filtration barrier. While the precise …

Nephrophilic autoantibodies dominate the seroprofile in lupus, but their fine specificities
remain ill defined. We constructed a multiplexed proteome microarray bearing about 30 …

Background: In nephrotic syndrome, damage to the podocytes of the kidney produces
severe hypercholesterolemia for which novel treatments are urgently needed. PCSK9 …

The morphology of healthy podocyte foot processes is necessary for maintaining the
characteristics of the kidney filtration barrier. In most forms of glomerular disease, abnormal …

Evidence suggests that the glycogen synthase kinase 3 (GSK3)–dictated nuclear exclusion
and degradation of Nrf2 is pivotal in switching off the self-protective antioxidant stress …