Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …

RNA decay plays a crucial role in post-transcriptional regulation of gene expression. Work
conducted over the last decades has defined the major mRNA decay pathways, as well as …

We developed PolyA-seq, a strand-specific and quantitative method for high-throughput
sequencing of 3′ ends of polyadenylated transcripts, and used it to globally map …

The liver plays a pivotal role in metabolism and xenobiotic detoxification, processes that
must be particularly efficient when animals are active and feed. A major question is how the …

The emerging discoveries on the link between polyadenylation and disease states underline
the need to fully characterize genome-wide polyadenylation states. Here, we report …

RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most
frequent and conserved type of RNA modification. The addition of tails and their composition …

Poly (A) tails have long been known as stable 3′ modifications of eukaryotic mRNAs,
added during nuclear pre‐mRNA processing. It is now appreciated that this modification is …

The eukaryotic RNA exosome is a ribonucleolytic complex involved in RNA processing and
turnover. It consists of a nine‐subunit catalytically inert core that serves a structural function …

The exosome is an exoribonuclease complex involved in the degradation and maturation of
a wide variety of RNAs. The nine‐subunit core of the eukaryotic exosome is catalytically …

Ribosome biogenesis requires multiple nuclease activities to process pre-rRNA transcripts
into mature rRNA species and eliminate defective products of transcription and processing …