Charting the path: navigating embryonic development to potentially safeguard against congenital heart defects

J Bragança, R Pinto, B Silva, N Marques… - Journal of Personalized …, 2023 - mdpi.com
Congenital heart diseases (CHDs) are structural or functional defects present at birth due to
improper heart development. Current therapeutic approaches to treating severe CHDs are …

WNT regulation of embryonic development likely involves pathways independent of nuclear CTNNB1

P Tribulo, JI Moss, M Ozawa, Z Jiang, XC Tian… - …, 2017 - repository.lsu.edu
Abstract© 2017 Society for Reproduction and Fertility. The bovine was used to examine the
potential for WNT signaling to affect the preimplantation embryo. Expression of seven key …

Spatiotemporal patterning of EpCAM is important for murine embryonic endo-and mesodermal differentiation

S Sarrach, Y Huang, S Niedermeyer, M Hachmeister… - Scientific Reports, 2018 - nature.com
Epithelial cell adhesion molecule EpCAM is expressed in pluripotent embryonic stem cells
(ESC) in vitro, but is repressed in differentiated cells, except epithelia and carcinomas …

A novel physiological culture system that mimics luteal angiogenesis

RS Robinson, AJ Hammond, GE Mann… - …, 2008 - rep.bioscientifica.com
Luteal inadequacy is a major cause of poor embryo development and infertility.
Angiogenesis, the formation of new blood vessels, is an essential process underpinning …

[HTML][HTML] A novel cardiac differentiation method of a large number and uniformly-sized spheroids using microfabricated culture vessels

T Miwa, A Idiris, H Kumagai - Regenerative Therapy, 2020 - Elsevier
Cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs) have
great potential for regenerative medicine and drug discovery. In this study, we developed a …

High-throughput 3D spheroid formation and effective cardiomyocyte differentiation from human iPS cells using the microfabric vessels EZSPHERETM

T Miwa, A Idiris, H Kumagai - Bio-protocol, 2021 - bio-protocol.org
High-throughput 3D spheroid formation from human induced pluripotent stem cells (hiPSCs)
can be easily performed using the unique microfabric vessels EZSPHERE, resulting in …

Inhibition of Histone Methyltransferase, Histone Deacetylase, and β‐Catenin Synergistically Enhance the Cardiac Potential of Bone Marrow Cells

J Yang, K Kaur, JG Edwards… - Stem cells …, 2017 - Wiley Online Library
Previously, we reported that treatment with the G9a histone methyltransferase inhibitor
BIX01294 causes bone marrow mesenchymal stem cells (MSCs) to exhibit a …

[HTML][HTML] The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis

A Hempel, SJ Kühl, M Rothe, PR Tata, IO Sirbu… - Developmental …, 2017 - Elsevier
Wnt proteins are critical for embryonic cardiogenesis and cardiomyogenesis by regulating
different intracellular signalling pathways. Whereas canonical Wnt/β-catenin signalling is …

Pentraxin 3 promotes cardiac differentiation of mouse embryonic stem cells through JNK signaling pathway

H Liu, Q Jiang, Z Ju, S Guan, B He - Cell Biology International, 2018 - Wiley Online Library
Cardiovascular disease is a leading cause of death worldwide, requiring the development of
new therapeutic strategies including stem cell therapy. Pentraxins (PTXs) are a superfamily …

A New Method for Chromosomes Preparation by ATP-Competitive Inhibitor SP600125 via Enhancement of Endomitosis in Fish

W Xu, Y Mo, Y He, Y Fan, G He, W Fu… - … in Bioengineering and …, 2021 - frontiersin.org
Previous studies have suggested that 1, 9-Pyrazoloanthrone, known as SP600125, can
induce cell polyploidization. However, what is the phase of cell cycle arrest caused by …