Neurobiology of cancer: the role of β-adrenergic receptor signaling in various tumor environments

B Mravec, L Horvathova, L Hunakova - International journal of molecular …, 2020 - mdpi.com
The development and progression of cancer depends on both tumor micro-and
macroenvironments. In addition, psychosocial and spiritual “environments” might also affect …

A literature perspective on the pharmacological applications of yohimbine

NR Jabir, CK Firoz, TA Zughaibi, MA Alsaadi… - Annals of …, 2022 - Taylor & Francis
Introduction: Phytochemicals have garnered much attention because they are useful in
managing several human diseases. Yohimbine is one such phytochemical with significant …

Stress, catecholaminergic system and cancer

O Krizanova, P Babula, K Pacak - Stress, 2016 - Taylor & Francis
Stress as a modern civilization factor significantly affects our lives. While acute stress might
have a positive effect on the organism, chronic stress is usually detrimental and might lead …

Use of non-selective β-blockers is associated with decreased tumor proliferative indices in early stage breast cancer

A Montoya, CN Amaya, A Belmont, N Diab… - …, 2016 - pmc.ncbi.nlm.nih.gov
Previous studies suggest beta-adrenergic receptor (β-AR) antagonists (β-blockers)
decrease breast cancer progression, tumor metastasis, and patient mortality; however the …

[HTML][HTML] Repurposing Drugs in Oncology (ReDO)—Propranolol as an anti-cancer agent

P Pantziarka, G Bouche, V Sukhatme… - …, 2016 - ncbi.nlm.nih.gov
Propranolol (PRO) is a well-known and widely used non-selective beta-adrenergic receptor
antagonist (beta-blocker), with a range of actions which are of interest in an oncological …

β-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives

M Coelho, C Soares-Silva, D Brandão, F Marino… - Journal of cancer …, 2017 - Springer
Purpose In this review, we aimed to present and discuss the available preclinical and
epidemiological evidences regarding the modulation of cancer cell proliferation by β …

Regulation of the autonomic nervous system on intestine

H Duan, X Cai, Y Luan, S Yang, J Yang… - Frontiers in …, 2021 - frontiersin.org
Intestine is composed of various types of cells including absorptive epithelial cells, goblet
cells, endocrine cells, Paneth cells, immunological cells, and so on, which play digestion …

Can stopping nerves, stop cancer?

JL Saloman, KM Albers, AD Rhim, BM Davis - Trends in neurosciences, 2016 - cell.com
The nervous system is viewed as a tissue affected by cancer and as a conduit for the
transmission of cancer pain and perineural invasion. Here, we review recent studies that …

[HTML][HTML] Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway

C Zhou, X Chen, W Zeng, C Peng, G Huang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Both preclinical and epidemiology studies associate β-adrenoceptors-blockers (β-blockers)
with activity against melanoma. However, the underlying mechanism is still unclear …

Surgical stress response and promotion of metastasis in colorectal cancer: a complex and heterogeneous process

C Behrenbruch, C Shembrey, S Paquet-Fifield… - Clinical & experimental …, 2018 - Springer
Surgery remains the curative treatment modality for colorectal cancer in all stages, including
stage IV with resectable liver metastasis. There is emerging evidence that the stress …