Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Mechanotransduction plays a crucial role in vascular biology. One example of this is the
local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The endothelium, although only a single layer of cells lining the vascular and lymphatic
systems, contributes in multiple ways to vascular homeostasis. Subsequent to the 1980 …

Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …

As the primary interface between the blood and various tissues of the body, the vascular
endothelium exhibits a diverse range of roles and activities, all of which contribute to the …

Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and
functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular …

Our view of the endothelium was transformed around 30 years ago, from one of an inert
barrier to that of a key endocrine organ central to cardiovascular function. This dramatic …

The Ca2+-activated K+ channel KCa3. 1 regulates membrane potential and calcium
signaling in erythrocytes, activated T and B cells, macrophages, microglia, vascular …