Inflammatory mechanisms in patients with chronic obstructive pulmonary disease

PJ Barnes - Journal of Allergy and Clinical Immunology, 2016 - Elsevier
Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation
affecting predominantly the lung parenchyma and peripheral airways that results in largely …

Cellular and molecular mechanisms of asthma and COPD

PJ Barnes - Clinical science, 2017 - portlandpress.com
Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction
and are associated with chronic inflammation of the airways. However, the nature and sites …

Cellular and molecular mechanisms of chronic obstructive pulmonary disease

PJ Barnes - Clinics in chest medicine, 2014 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute …

CXCR3 in T cell function

JR Groom, AD Luster - Experimental cell research, 2011 - Elsevier
CXCR3 is a chemokine receptor that is highly expressed on effector T cells and plays an
important role in T cell trafficking and function. CXCR3 is rapidly induced on naïve cells …

New insights into the immunology of chronic obstructive pulmonary disease

GG Brusselle, GF Joos, KR Bracke - The Lancet, 2011 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome associated
with abnormal inflammatory immune responses of the lung to noxious particles and gases …

The chemotaxis of M1 and M2 macrophages is regulated by different chemokines

W Xuan, Q Qu, B Zheng, S Xiong… - Journal of Leucocyte …, 2015 - academic.oup.com
The homing of proinflammatory (M1) and the “alternatively activated” anti-inflammatory (M2)
macrophages plays a different role in the process of inflammation. Chemokines are the …

CXCR3 ligands: redundant, collaborative and antagonistic functions

JR Groom, AD Luster - Immunology and cell biology, 2011 - Wiley Online Library
CXCR3 is a chemokine receptor that is rapidly induced on naïve T cells following activation,
and preferentially remains highly expressed on type‐1 helper (Th1)‐type CD4+ T cells …

Immunology of asthma and chronic obstructive pulmonary disease

PJ Barnes - Nature Reviews Immunology, 2008 - nature.com
Asthma and chronic obstructive pulmonary disease (COPD) are both obstructive airway
diseases that involve chronic inflammation of the respiratory tract, but the type of …

The cytokine network in asthma and chronic obstructive pulmonary disease

PJ Barnes - The Journal of clinical investigation, 2008 - Am Soc Clin Investig
Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory
diseases of the airways. They both cause airway narrowing and are increasing in incidence …

Immunologic aspects of chronic obstructive pulmonary disease

MG Cosio, M Saetta, A Agusti - New England Journal of Medicine, 2009 - Mass Medical Soc
This review is an account of how pulmonary damage caused by cigarette smoke and other
environmental toxins can incite inflammatory and immunologic reactions that culminate in …