Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …

Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from∼
250× 140× 90 μm 3 of electron microscopic images, including pyramidal and non-pyramidal …

Background Ischemic stroke can induce changes in mitochondrial morphology and function.
As a regulatory gene in mitochondria, optic atrophy 1 (OPA1) plays a pivotal role in the …

Mitochondria play a critical role in regulating cellular functions including bioenergetics,
calcium homeostasis, redox signalling, and apoptotic cell death. Mitochondria are also …

Apoptosis plays a major role in shaping the developing nervous system during
embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons …

Macrophages are essential players for the host response against pathogens, regulation of
inflammation and tissue regeneration. The wide range of macrophage functions rely on their …

Neurons are highly polarised, complex and incredibly energy intensive cells, and their
demand for ATP during neuronal transmission is primarily met by oxidative phosphorylation …

Appropriate cristae remodeling is a determinant of mitochondrial function and bioenergetics
and thus represents a crucial process for cellular metabolic adaptations. Here, we show that …

Astrocytes are the major glial cell in the central nervous system. These polarized cells
possess numerous processes that ensheath the vasculature and contact synapses …