▪ Abstract Calcium-activated chloride channels (CaCCs) play important roles in cellular
physiology, including epithelial secretion of electrolytes and water, sensory transduction …

Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …

Abstract Calcium (Ca2+)-activated chloride channels are fundamental mediators in
numerous physiological processes including transepithelial secretion, cardiac and neuronal …

Calcium-dependent chloride channels are required for normal electrolyte and fluid
secretion, olfactory perception, and neuronal and smooth muscle excitability. The molecular …

Calcium-activated chloride channels (CaCCs) are major regulators of sensory transduction,
epithelial secretion, and smooth muscle contraction. Other crucial roles of CaCCs include …

Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are
hallmark features of inflammatory airway diseases, including asthma. Here, we show that the …

TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). We
developed pharmacological tools to investigate the contribution of TMEM16A to CaCC …

Calcium-activated chloride channels (CaCC) with similar hallmark features are present in
many cell types and mediate important physiological functions including epithelial secretion …

This article reviews the current state of knowledge about the bestrophins, a newly identified
family of proteins that can function both as Cl− channels and as regulators of voltage-gated …

Anoctamin (ANO)/TMEM16 proteins exhibit diverse functions in cells throughout the body
and are implicated in several human diseases. Although the founding members ANO1 …