A decennary update on diverse heterocycles and their intermediates as privileged scaffolds for cathepsin B inhibition
The identification of x-ray crystal structure of cathepsin B (CTSB) in the early 90's enabled
researchers to embark on a journey to understand and demystify its multiple catalytic …
researchers to embark on a journey to understand and demystify its multiple catalytic …
[HTML][HTML] Novel 1, 2, 3-triazole-aurone hybrids as cathepsin B inhibitors: One-pot synthesis, anti-proliferative, and drug modeling studies
In the present study, we have designed a series of novel 1, 2, 3-triazole-aurone hybrids,
which were synthesized by a one-pot click reaction between a terminal alkyne and an in-situ …
which were synthesized by a one-pot click reaction between a terminal alkyne and an in-situ …
Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR
Prostate cancer is a disease that is affecting a large population worldwide. Androgen
deprivation therapy (ADT) has become a foundation for the treatment of advanced prostate …
deprivation therapy (ADT) has become a foundation for the treatment of advanced prostate …
Dihydronaphthalenone chalconoid derivatives as potential cathepsin B inhibitors; design, synthesis, cytotoxicity evaluation and docking analysis
S Ranjbar, MR Shabanpoor, Z Dehghani… - Brazilian Journal of …, 2021 - SciELO Brasil
Cathepsin B, an abundant expressed cysteine peptidase, plays a key role in cancer cell
proliferation, tumor metastasis, apoptosis, angiogenesis, invasion and migration. Therefore …
proliferation, tumor metastasis, apoptosis, angiogenesis, invasion and migration. Therefore …
Mechanism underlying the inhibitory effect of bio-synthesized silver nanoparticle on TNF-α induced NF-κB nuclear translocation in prostate cancer cells
K Rajathi, KB Leneeygreen, S Suja - International Journal of …, 2021 - ijpsnonline.com
Apoptosis, a physiological mechanism of highly orchestrated cell death, can be initiated by
extracellular and intracellular mechanisms that trigger a complex machinery of proapoptotic …
extracellular and intracellular mechanisms that trigger a complex machinery of proapoptotic …
[PDF][PDF] Synthesis and Biological Evaluation of Some Novel Chalcone Derivatives as an Antiinflammatory Agents
AA Ahamed, MM Sihabudeen… - World Journal …, 2018 - wjpr.s3.ap-south-1.amazonaws.com
ABSTRACT A series of chalcones was synthesized using Claisen-Schmidt condensation
reaction by acetanilide with formyl morphiline. The resulting chalcones after purification …
reaction by acetanilide with formyl morphiline. The resulting chalcones after purification …