Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

Elevations in glucocorticoids that result from environmental stressors can have programming
effects on brain structure and function when the exposure occurs during sensitive periods …

Schizophrenia is a severe mental disorder with an unclear pathophysiology. Increased
expression of the immune gene C4 has been linked to a greater risk of developing …

Chronic stress‐related psychiatric diseases, such as major depression, posttraumatic stress
disorder, and schizophrenia, are characterized by a maladaptive organization of behavioral …

Repeated exposure to stress during childhood is associated with increased risk for
neuropsychiatric illness, substance use disorders and other behavioral problems in …

Long-term shift work can cause circadian misalignment, which has been linked to anxiety
and depression. However, the associated pathophysiologic changes have not been …

Abnormal potentiation in the lateral habenula (LHb) has been suggested to mediate
depression-like behaviors. However, the underlying mechanisms of the synaptic efficacy …

Adolescent exposure to social stress precipitates emotion-related disorders and affects the
development and function of medial prefrontal cortex (mPFC). However, this adversity …

Resilience to stress is the ability to quickly adapt to adversity. There is evidence that
exposure to prolonged stress triggers neuroinflammation what produces individual …

Background Early-life adversities during development (eg, child abuse and neglect) are
linked to multiple behavioral and cognitive dysfunctions, such as attention …