During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine
mucosa without being rejected by the maternal immune system. Several mechanisms were …

T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …

Fibrosis affects millions of people with cardiac disease. We developed a therapeutic
approach to generate transient antifibrotic chimeric antigen receptor (CAR) T cells in vivo by …

Chimeric antigen receptors (CARs) are synthetic antigen receptors that reprogram T cell
specificity, function and persistence. Patient-derived CAR T cells have demonstrated …

Destruction of cancer cells by therapeutic antibodies occurs, at least in part, through
antibody-dependent cellular cytotoxicity (ADCC), and this can be mediated by various Fc …

Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but
whether this interaction has physiological consequences on DC function is largely …

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex
microenvironment. Dichotomous tumour-promoting and-restrictive roles have been ascribed …

The recognition events that mediate adaptive cellular immunity and regulate antibody
responses depend on intercellular contacts between T cells and antigen-presenting cells …

The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

The transfer of molecules between cells during cognate immune cell interactions has been
reported, and recently a novel mechanism of transfer of proteins and genetic material such …