The generation of anti-tumor immunity in the draining lymph nodes is known as the cancer
immunity cycle. Accumulating evidence supports the occurrence of such a cycle at tumor …

As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated
immune responses. Although the crucial function of these CD4+ T cells in infection and …

Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates where
adaptive antitumour cellular and humoral responses can be elaborated. Initially described in …

Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …

Dimeric IgA (dIgA) can move through cells via the IgA/IgM polymeric immunoglobulin
receptor (PIGR), which is expressed mainly on mucosal epithelia. Here, we studied the …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

T follicular helper (Tfh) cells specialize in helping B cells and are therefore critical
contributors to the generation of humoral immunity. Tfh cells aid immunoglobulin class …

Biomarkers guiding the neoadjuvant use of immune-checkpoint blockers (ICB) are needed
for patients with localized muscle-invasive bladder cancers (MIBC). Profiling tumor and …

The lack of sufficient intratumoral CD8+ T lymphocytes is a significant obstacle to effective
immunotherapy in cancer. High endothelial venules (HEVs) are organ-specific and …