Structural basis of response regulator function

R Gao, S Bouillet, AM Stock - Annual review of microbiology, 2019 - annualreviews.org
Response regulators function as the output components of two-component systems, which
couple the sensing of environmental stimuli to adaptive responses. Response regulators …

Two-component systems regulate bacterial virulence in response to the host gastrointestinal environment and metabolic cues

C Shaw, M Hess, BC Weimer - Virulence, 2022 - Taylor & Francis
Two-component systems are ubiquitous signaling mechanisms in bacteria that enable
intracellular changes from extracellular cues. These bacterial regulatory systems couple …

Retapamulin-assisted ribosome profiling reveals the alternative bacterial proteome

S Meydan, J Marks, D Klepacki, V Sharma, PV Baranov… - Molecular cell, 2019 - cell.com
The use of alternative translation initiation sites enables production of more than one protein
from a single gene, thereby expanding the cellular proteome. Although several such …

Environmental adaptation and diversification of bacterial two-component systems

AF Alvarez, D Georgellis - Current Opinion in Microbiology, 2023 - Elsevier
Bacterial two-component systems (TCS) are versatile signaling mechanisms that govern
cellular responses to diverse environmental cues. These systems rely on phosphoryl-group …

[HTML][HTML] Two-component system GacS/GacA, a global response regulator of bacterial physiological behaviors

H Song, Y Li, Y Wang - Engineering Microbiology, 2023 - Elsevier
The signal transduction system of microorganisms helps them adapt to changes in their
complex living environment. Two-component system (TCS) is a representative signal …

Succession of the bacterial community structure and functional prediction in two composting systems viewed through metatranscriptomics

J Ding, D Wei, Z An, C Zhang, L Jin, L Wang, Y Li… - Bioresource …, 2020 - Elsevier
Abstract In this work, Illumina MiSeq sequencing of cDNA from metatranscriptomics RNA
reverse transcription were employed in combination with phylogenetic investigation of …

Real-time detection of response regulator phosphorylation dynamics in live bacteria

RJ Butcher, JJ Tabor - … of the National Academy of Sciences, 2022 - National Acad Sciences
Bacteria utilize two-component system (TCS) signal transduction pathways to sense and
adapt to changing environments. In a typical TCS, a stimulus induces a sensor histidine …

The role of sensory kinase proteins in two-component signal transduction

AF Alvarez, D Georgellis - Biochemical Society Transactions, 2022 - portlandpress.com
Two-component systems (TCSs) are modular signaling circuits that regulate diverse aspects
of microbial physiology in response to environmental cues. These molecular circuits …

Hybrid histidine kinase activation by cyclic di-GMP–mediated domain liberation

BN Dubey, E Agustoni, R Böhm… - Proceedings of the …, 2020 - National Acad Sciences
Cytosolic hybrid histidine kinases (HHKs) constitute major signaling nodes that control
various biological processes, but their input signals and how these are processed are …

[HTML][HTML] BarA/UvrY differentially regulates prodigiosin biosynthesis and swarming motility in Serratia marcescens FS14

X Liu, D Xu, D Wu, M Xu, Y Wang, W Wang… - Research in …, 2023 - Elsevier
BarA/UvrY, a two-component system and global regulator that controls expression of more
than a hundred of genes involved in virulence, motility, biofilm formation, and central carbon …