The heterotrimeric RNA-dependent RNA polymerase of influenza viruses catalyzes RNA
replication and transcription activities in infected cell nuclei. The nucleotide polymerization …

Influenza virus is a negative strand RNA virus and is one of the rare RNA viruses to replicate
in the nucleus. The viral RNA is associated with 4 viral proteins to form ribonucleoprotein …

The influenza virus polymerase transcribes or replicates the segmented RNA genome (viral
RNA) into viral messenger RNA or full-length copies. To initiate RNA synthesis, the …

Influenza A virus segment 2 is known to encode two polypeptides in overlapping open
reading frames: PB1, the polymerase, and PB1-F2, a proapoptotic virulence factor. We show …

A single amino acid substitution, from glutamic acid to lysine at position 627 of the PB2
protein, converts a nonlethal H5N1 influenza A virus isolated from a human to a lethal virus …

The recent emergence of highly pathogenic avian influenza A virus strains with subtype
H5N1 pose a global threat to human health. Elucidation of the underlying mechanisms of …

The influenza A viruses are the causative agents of respiratory disease that occurs as yearly
epidemics and occasional pandemics. These viruses are endemic in wild avian species and …

Polymerase basic protein 1 (PB1) is the catalytic core of the influenza A virus (IAV) RNA
polymerase complex essential for viral transcription and replication. Understanding the …

The outbreaks of avian influenza A virus in poultry and humans over the last decade posed
a pandemic threat to human. Here, we discuss the basic classification and the structure of …

Influenza viruses are major human pathogens responsible for respiratory diseases affecting
millions of people worldwide and characterized by high morbidity and significant mortality …