Ethical considerations of the vaccine development process and vaccination: a scoping review
Background Various vaccines have been developed and distributed worldwide to control
and cope with COVID-19 disease. To ensure vaccines benefit the global community, the …
and cope with COVID-19 disease. To ensure vaccines benefit the global community, the …
Testing fractional doses of COVID-19 vaccines
W Więcek, A Ahuja, E Chaudhuri… - Proceedings of the …, 2022 - National Acad Sciences
Due to the enormous economic, health, and social costs of the COVID-19 pandemic, there
are high expected social returns to investing in parallel in multiple approaches to …
are high expected social returns to investing in parallel in multiple approaches to …
SARS-CoV-2 entry into and evolution within a skilled nursing facility
NR Sexton, PJ Cline, EN Gallichotte, E Fitzmeyer… - Scientific Reports, 2023 - nature.com
SARS-CoV-2 belongs to the family Coronaviridae which includes multiple human pathogens
that have an outsized impact on aging populations. As a novel human pathogen, SARS-CoV …
that have an outsized impact on aging populations. As a novel human pathogen, SARS-CoV …
Clinical trials for accelerating pandemic vaccines
W Więcek - Oxford Review of Economic Policy, 2022 - academic.oup.com
We provide a short overview of clinical trials of vaccines, with particular focus on (i) adaptive
and platform trials,(ii) human challenge trials, and (iii) vaccine use optimization, especially …
and platform trials,(ii) human challenge trials, and (iii) vaccine use optimization, especially …
Global systemic risk and resilience for novel coronavirus and COVID‐19
Abstract This Special Issue is dedicated to issues and challenges related to pandemic risk
and resilience, with a focus on policy and operations of global systems in the COVID‐19 …
and resilience, with a focus on policy and operations of global systems in the COVID‐19 …
Research ethics and public trust in vaccines: the case of COVID-19 challenge trials
N Eyal - Journal of Medical Ethics, 2024 - jme.bmj.com
Despite their clearly demonstrated safety and effectiveness, approved vaccines against
COVID-19 are commonly mistrusted. Nations should find and implement effective ways to …
COVID-19 are commonly mistrusted. Nations should find and implement effective ways to …
The case for human challenge trials in COVID-19
GP Drewett - Journal of Bioethical Inquiry, 2024 - Springer
The COVID-19 pandemic has necessitated rapid research to aid in the understanding of the
disease and the development of novel therapeutics. One option is to conduct controlled …
disease and the development of novel therapeutics. One option is to conduct controlled …
COVID vaccine efficacy against the B. 1.351 (“South African”) variant—The urgent need to lay the groundwork for possible future challenge studies
SARS-CoV-2's B. 1.351 (“South African”) variant “is markedly more resistant to neutralization
by convalescent plasma (9.4 fold) and vaccinee sera (10.3–12.4 fold),” 1, 2 raising the …
by convalescent plasma (9.4 fold) and vaccinee sera (10.3–12.4 fold),” 1, 2 raising the …
Could Vaccine Dose Stretching Reduce COVID-19 Deaths?
We argue that alternative COVID-19 vaccine dosing regimens could potentially dramatically
accelerate global COVID-19 vaccination and reduce mortality, and that the costs of testing …
accelerate global COVID-19 vaccination and reduce mortality, and that the costs of testing …
Do coronavirus vaccine challenge trials have a distinctive generalisability problem?
Notwithstanding the success of conventional field trials for vaccines against COVID-19,
human challenge trials (HCTs) that could obtain more information about these and about …
human challenge trials (HCTs) that could obtain more information about these and about …