Prefrontal cortical regulation of REM sleep
Rapid eye movement (REM) sleep is accompanied by intense cortical activity, underlying its
wake-like electroencephalogram. The neural activity inducing REM sleep is thought to …
wake-like electroencephalogram. The neural activity inducing REM sleep is thought to …
Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus
The prefrontal cortex (PFC) enables mammals to respond to situations, including internal
states, with appropriate actions. One such internal state could be 'tiredness'. Here, using …
states, with appropriate actions. One such internal state could be 'tiredness'. Here, using …
Advanced neurobiological tools to interrogate metabolism
PN Mirabella, H Fenselau - Nature Reviews Endocrinology, 2023 - nature.com
Engineered neurobiological tools for the manipulation of cellular activity, such as
chemogenetics and optogenetics, have become a cornerstone of modern neuroscience …
chemogenetics and optogenetics, have become a cornerstone of modern neuroscience …
The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation
Measures of fMRI resting-state functional connectivity (rs-FC) are an essential tool for basic
and clinical investigations of fronto-limbic circuits. Understanding the relationship between …
and clinical investigations of fronto-limbic circuits. Understanding the relationship between …
The role of orexin neuron activity in sleep/wakefulness regulation
C Hung, A Yamanaka - Peptides, 2023 - Elsevier
Orexin (also known as hypocretin) is a neuropeptide exclusively synthesized in the neurons
of the lateral hypothalamus (LH). Initially orexin was thought to be involved in the regulation …
of the lateral hypothalamus (LH). Initially orexin was thought to be involved in the regulation …
Activation of basal forebrain astrocytes induces wakefulness without compensatory changes in sleep drive
AM Ingiosi, CR Hayworth, MG Frank - Journal of Neuroscience, 2023 - Soc Neuroscience
Mammalian sleep is regulated by a homeostatic process that increases sleep drive and
intensity as a function of prior wake time. Sleep homeostasis has traditionally been thought …
intensity as a function of prior wake time. Sleep homeostasis has traditionally been thought …
Deschloroclozapine exhibits an exquisite agonistic effect at lower concentration compared to clozapine-N-oxide in hM3Dq expressing chemogenetically modified rats
M Shimizu, M Yoshimura, K Baba, N Ikeda… - Frontiers in …, 2023 - frontiersin.org
Introduction Within the realm of chemogenetics, a particular form of agonists targeting
designer receptors exclusively activated by designer drugs (DREADDs) has emerged …
designer receptors exclusively activated by designer drugs (DREADDs) has emerged …
A medullary hub for controlling REM sleep and pontine waves
Abstract Rapid-eye-movement (REM) sleep is a distinct behavioral state associated with
vivid dreaming and memory processing. Phasic bursts of electrical activity, measurable as …
vivid dreaming and memory processing. Phasic bursts of electrical activity, measurable as …
Neocortical long-range inhibition promotes cortical synchrony and sleep
Behavioral states such as sleep and wake are highly correlated with specific patterns of
rhythmic activity in the cortex. During low arousal states such as slow wave sleep, the cortex …
rhythmic activity in the cortex. During low arousal states such as slow wave sleep, the cortex …
Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state
Infradian mood and sleep-wake rhythms with periods of 48 hours and beyond have been
observed in patients with bipolar disorder (BD), which even persist in the absence of …
observed in patients with bipolar disorder (BD), which even persist in the absence of …