Super-resolution imaging techniques that overcome the diffraction limit of light have gained
wide popularity for visualizing cellular structures with nanometric resolution. Following the …

Cryogenic electron microscopy and data processing enable the determination of structures
of isolated macromolecules to near-atomic resolution. However, these data do not provide …

Since their inception in the 1930–1960s, the research disciplines of computational imaging
and machine learning have followed parallel tracks and, during the last two decades …

Fluorescence nanoscopy uniquely combines minimally invasive optical access to the
internal nanoscale structure and dynamics of cells and tissues with molecular detection …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

The field of nanocrystal quantum dots (QDs) is already more than 30 years old, and yet
continuing interest in these structures is driven by both the fascinating physics emerging …

Fluorescence spectroscopy with strong emitters is a remarkable tool with ultra-high
sensitivity for detection and imaging down to the single-molecule level. Plasmon-enhanced …

Single-molecule (SM) surface-enhanced Raman spectroscopy (SERS) and tip-enhanced
Raman spectroscopy (TERS) have emerged as analytical techniques for characterizing …

Over the past 20 years, protein engineering has been extensively used to improve and
modify the fundamental properties of fluorescent proteins (FPs) with the goal of adapting …

Single-molecule super-resolution fluorescence microscopy and single-particle tracking are
two imaging modalities that illuminate the properties of cells and materials on spatial scales …