Covering: 1996–December 2016 The human Ether-à-go-go Related Gene (hERG) channel
is a voltage-gated potassium channel playing an essential role in the normal electrical …

Automated patch clamp (APC) technology was first developed at the turn of the millennium.
The increased throughput it afforded promised a new paradigm in ion channel recordings …

Recent progress in embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC)
research led to high-purity preparations of human cardiomyocytes (CMs) differentiated from …

Introduction Early prediction of drug-induced functional cardiotoxicity requires robust in-vitro
systems suitable for medium/high throughput and easily accessible cardiomyocytes with …

Patch clamp electrophysiology has transformed research in the life sciences over the last
few decades. Since their inception, automatic patch clamp platforms have evolved …

Understanding the mechanism of toxicity of nanomaterials remains a challenge with respect
to both mechanisms involved and product regulation. Here we show toxicity of ultrasmall …

Advances in next-generation sequencing have been exceptionally valuable for identifying
variants in medically actionable genes. However, for most missense variants there is …

The patch clamp technique, developed in late 1970s, started a new period of experimental
cardiac electrophysiology enabling measurement of ionic currents on isolated …

We have developed an automated patch clamp module for high-throughput ion channel
screening, recording from 384 cells simultaneously. The module is incorporated into a …

Voltage-gated sodium (NaV) channels have an essential role in the initiation and
propagation of action potentials in excitable cells, such as neurons. Of these channels …