Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Tropical countries are experiencing a substantial rise in type 2 diabetes, which is often
undiagnosed or poorly controlled. Since diabetes is a risk factor for many infectious …

High-throughput single-cell RNA-sequencing (scRNA-seq) methodologies enable
characterization of complex biological samples by increasing the number of cells that can be …

Leprosy is caused by Mycobacterium leprae (M. leprae) and M. lepromatosis, an obligate
intracellular organism, and over 200,000 new cases occur every year. M. leprae parasitizes …

Erythema nodosum leprosum (ENL) is a painful inflammatory complication of leprosy
occurring in 50% of lepromatous leprosy patients and 5–10% of borderline lepromatous …

Leprosy is a chronic infectious disease whose evolution involves complex immune
mechanisms of the host that influence the clinical presentation of the disease. For many …

Leprosy is a disease caused by Mycobacterium leprae (ML) with diverse clinical
manifestations, which are strongly correlated with the host's immune response. Skin lesions …

Background 50% of leprosy patients suffer from episodes of Type 1/reversal reactions (RR)
and Type 2/Erythema Nodosum Leprosum (ENL) reactions which lead to morbidity and …

T cell defect is a common feature in lepromatous or borderline lepromatous leprosy (LL/BL)
patients in contrast to tuberculoid or borderline tuberculoid type (TT/BT) patients …

Leprosy is still a considerable health threat in pockets of several low and middle income
countries worldwide where intense transmission is witnessed, and often results in …