Microfluidic chips: recent advances, critical strategies in design, applications and future perspectives

P Pattanayak, SK Singh, M Gulati, S Vishwas… - Microfluidics and …, 2021 - Springer
Microfluidic chip technology is an emerging tool in the field of biomedical application.
Microfluidic chip includes a set of groves or microchannels that are engraved on different …

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

H Liu, Y Wang, K Cui, Y Guo, X Zhang… - Advanced …, 2019 - Wiley Online Library
Significant advances in materials, microscale technology, and stem cell biology have
enabled the construction of 3D tissues and organs, which will ultimately lead to more …

[HTML][HTML] Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

M Kasendra, A Tovaglieri, A Sontheimer-Phelps… - Scientific reports, 2018 - nature.com
Here we describe a method for fabricating a primary human Small Intestine-on-a-Chip
(Intestine Chip) containing epithelial cells isolated from healthy regions of intestinal …

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

JU Lind, TA Busbee, AD Valentine, FS Pasqualini… - Nature materials, 2017 - nature.com
Biomedical research has relied on animal studies and conventional cell cultures for
decades. Recently, microphysiological systems (MPS), also known as organs-on-chips, that …

Phototactic guidance of a tissue-engineered soft-robotic ray

SJ Park, M Gazzola, KS Park, S Park, V Di Santo… - Science, 2016 - science.org
Inspired by the relatively simple morphological blueprint provided by batoid fish such as
stingrays and skates, we created a biohybrid system that enables an artificial animal—a …

Microfluidic organs-on-chips

SN Bhatia, DE Ingber - Nature biotechnology, 2014 - nature.com
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …

Programming cellular alignment in engineered cardiac tissue via bioprinting anisotropic organ building blocks

JH Ahrens, SGM Uzel, M Skylar‐Scott… - Advanced …, 2022 - Wiley Online Library
The ability to replicate the 3D myocardial architecture found in human hearts is a grand
challenge. Here, the fabrication of aligned cardiac tissues via bioprinting anisotropic organ …

Organs-on-chips at the frontiers of drug discovery

EW Esch, A Bahinski, D Huh - Nature reviews Drug discovery, 2015 - nature.com
Improving the effectiveness of preclinical predictions of human drug responses is critical to
reducing costly failures in clinical trials. Recent advances in cell biology, microfabrication …

High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

[HTML][HTML] Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

S Halldorsson, E Lucumi, R Gómez-Sjöberg… - Biosensors and …, 2015 - Elsevier
Culture of cells using various microfluidic devices is becoming more common within
experimental cell biology. At the same time, a technological radiation of microfluidic cell …