Avermectins are a group of drugs that occurs naturally as a product of fermenting
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …

The goals of this German guideline are the improvement of diagnosis and therapy of
scabies, the implementation of a coordinated action in outbreaks of scabies, and the control …

Ivermectin is a pivotal drug for the control of onchocerciasis and lymphatic filariasis, which is
increasingly identified as a useful drug for the control of other Neglected Tropical Diseases …

Background: Onchocerciasis (river blindness), caused by the filarial worm species
Onchocerca volvulus, is a serious vector-borne neglected tropical disease (NTD) of public …

Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

Finding new chemotherapeutic interventions to treat malaria through repurposing of time-
tested drugs and rigorous design of new drugs using tools of rational drug design remains …

Aims The anthelminthic ivermectin is receiving new attention as it is being repurposed for
new indications such as mass drug administrations for the treatment of scabies or in malaria …

Ivermectin and moxidectin are the most widely administered anthelmintic macrocyclic
lactones (MLs) to treat human and animal nematode infections. Their widespread and …

Methods HIV/AIDS patients were recruited from Themba Lethu Clinic, at Helen Joseph
Hospital, Johannesburg. Blood samples for plasma drug levels and DNA extraction were …

Adenosine triphosphate–binding cassette subfamily B member 1 (ABCB1), also known as
permeability glycoprotein, multidrug-resistant protein 1, or cluster of differentiation 243 …