During embryonic morphogenesis, the heart undergoes a complex series of cellular
phenotypic maturations (eg, transition of myocytes from proliferative to quiescent or …

Cells are a fundamental structural, functional and biological unit for all living organisms. Up
till now, considerable efforts have been made to study the responses of single cells and …

We present a general model of actin filament deformation and fragmentation in response to
compressive forces. The elastic free energy density along filaments is determined by their …

Wednesday, February 6, 2013 549a fragmentation of partially decorated filaments at
boundaries of bare and cofilindecorated segments. Despite extensive evidence for cofilin …

Cells are able to respond to mechanical forces and deformations. The actin cytoskeleton, a
highly dynamic scaffolding structure, plays an important role in cell mechano-sensing. Thus …

Experiments have shown that actin is structurally polymorphic, but knowledge of the details
of molecular level heterogeneity in both the dynamics of a single subunit and the …

In this paper, we report the results of molecular dynamics simulations of AXH monomer of
Ataxin‐1. The AXH domain plays a crucial role in Ataxin‐1 aggregation, which accompanies …

Traumatic brain injuries have recently been put under the spotlight as one of the most
important causes of accidental brain dysfunctions. Significant experimental and modeling …

This review focuses on modeling techniques developed for prediction of mechanical
properties and characterization of microtubules, polyatomic structures that contain billions of …

Integrin conformational dynamics are critical to their receptor and signaling functions in
many cellular processes, including spreading, adhesion, and migration. However, assessing …