Pathogenic cellular and molecular mediators in lupus nephritis

C Mohan, T Zhang, C Putterman - Nature Reviews Nephrology, 2023 - nature.com
Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …

T follicular helper cells in autoimmune diseases

X Wei, X Niu - Journal of Autoimmunity, 2023 - Elsevier
T follicular helper (Tfh) cells with the phenotype of mainly expressing surface molecules
CXC motif chemokine receptor type 5 (CXCR5), inducible co-stimulator (ICOS), secreting …

COVID-19 vaccination followed by activation of glomerular diseases: does association equal causation?

NL Li, PT Coates, BH Rovin - Kidney International, 2021 - kidney-international.org
To date,> 4 billion doses of the various severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) vaccines have been administered worldwide in response to the coronavirus …

Expanded circulating peripheral helper T cells in systemic lupus erythematosus: association with disease activity and B cell differentiation

A Makiyama, A Chiba, D Noto, G Murayama… - …, 2019 - academic.oup.com
Abstract Objective Peripheral helper T (TPH) cells are a recently identified Th cell subset that
promotes B cell differentiation and antibody production in inflamed tissues. This study …

PD-1+CXCR5CD4+T cells are correlated with the severity of systemic lupus erythematosus

J Lin, Y Yu, J Ma, C Ren, W Chen - Rheumatology, 2019 - academic.oup.com
Abstract Objectives PD-1+ CXCR5− CD4+ T peripheral helper (Tph) cells, a recently
identified T cell subset, are proven to promote B cell responses and antibody production in …

Follicular helper T cells in the pathogenesis of IgG4-related disease

M Akiyama, K Suzuki, H Yasuoka, Y Kaneko… - …, 2018 - academic.oup.com
Abstract IgG4-related disease (IgG4-RD) is a recently recognized disease entity
characterized by high serum IgG4 concentrations and infiltration of IgG4+ plasma cells with …

Rituximab in systemic lupus erythematosus: transient effects on autoimmunity associated lymphocyte phenotypes and implications for immunogenicity

F Faustini, N Sippl, R Stålesen, K Chemin… - Frontiers in …, 2022 - frontiersin.org
B cell abnormalities are common in systemic lupus erythematosus (SLE), and include
expansion of double negative (DN) and age-associated-like B cells (ABC-like). We aimed to …

Baicalin ameliorates lupus autoimmunity by inhibiting differentiation of Tfh cells and inducing expansion of Tfr cells

J Yang, X Yang, J Yang, M Li - Cell death & disease, 2019 - nature.com
Baicalin is a natural compound isolated from Chinese herb, which has been reported as an
anti-inflammatory drug. Here, we demonstrated that Baicalin treatment could reduce urine …

Inflammatory biomarkers in postural orthostatic tachycardia syndrome with elevated G-protein-coupled receptor autoantibodies

WT Gunning III, SM Stepkowski, PM Kramer… - Journal of Clinical …, 2021 - mdpi.com
A growing body of evidence suggests that postural orthostatic tachycardia syndrome (POTS)
may be an autoimmune disorder. We have reported in a previous manuscript that 89% of …

PD-L1-and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus

J Tchen, Q Simon, L Chapart, MK Thaminy… - Nature …, 2024 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-
nuclear autoantibodies whose production is promoted by autoreactive T follicular helper …