Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration
combined with safety and few, yet rare, unwanted effects, have made the quinolones class of …

Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …

Quinoline and quinolone motifs which act as structural subunits of more complex natural
products are ubiquitous in nature, and they are useful pharmacophores which play a pivotal …

Fluoroquinolones remain one of the most important kind of antibacterial agents used
nowadays. The emergence of more virulent and resistant strains of bacteria by the …

The emergence and wide-spread of drug-resistant bacteria including multi-drug resistant
and pan-drug resistant pathogens which are associated with considerable mortality …

Gram-positive bacteria are responsible for a broad range of infectious diseases, and the
emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA …

The emergence of bacterial resistance has motivated researchers to discover new
antibacterial agents. Nowadays, fluoroquinolones keep their status as one of the essential …

Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

This review is aimed to provide extensive survey of quinolones and fluoroquinolones for a
variety of applications ranging from metal complexes and nanoparticle development to …

Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …