Background Gastric cancer imposes a substantial global health burden despite its overall
incidence decrease. A broad spectrum of inherited, environmental and infectious factors …

Despite recent advancements in understanding of the biology of gastric cancer, treatment of
patients with advanced gastric cancer remains a major problem. Among different type of …

Gastrointestinal (GI) cancers with a high global prevalence are a leading cause of morbidity
and mortality. Accordingly, there is a great need to develop efficient therapeutic approaches …

Curcumin is a small organic molecule with pleiotropic biological activities. However, its
multiple structural-pharmacokinetic challenges prevent its development into a clinical drug …

Gastric cancer is a common oncological disease. Although enormous efforts have been
expended, possible therapeutic modalities are still limited. For this reason, new therapeutic …

EF24 and F35 both were effective monocarbonyl curcumin analogues (MCACs) with
excellent anti-tumor activity, however, drug defect such as toxicity may limit their further …

Curcumin is a natural medicine with a wide range of anti-tumour activities. However, due to
β-diketone moiety, curcumin exhibits poor stability and pharmacokinetics which significantly …

The importance of inflammation in the pathogenesis of cancer was first proposed by
Rudolph Virchow over 150 years ago, and our understanding of its significance has grown …

Gastric cancer is the fifth most common cancer globally and the third leading cause of
cancer-related deaths. Researchers have been investigating natural compounds as …

The structure-activity relationship (SAR) between toxicity and the types of linking ketones of
C7 bridged monocarbonyl curcumin analogs (MCAs) was not clear yet. In the pursuit of …