Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Selective covalent modification of a targeted protein is a powerful tool in chemical biology
and drug discovery, with applications ranging from identification and characterization of …

Artificial intelligence-based protein structure prediction approaches have had a
transformative effect on biomolecular sciences. The predicted protein models in the …

Arylfluorosulfates have appeared only rarely in the literature and have not been explored as
probes for covalent conjugation to proteins, possibly because they were assumed to …

Cellular retinoic acid-binding protein II (CRABP-II) undergoes nuclear translocation upon
binding of retinoic acid (RA). In the nucleus, CRABP-II directly binds to the nuclear receptor …

Retinoids, such as all-trans-retinoic acid (ATRA), are endogenous signaling molecules
derived from vitamin A that influence a variety of cellular processes through mediation of …

Die selektive kovalente Modifikation eines Zielproteins wird in der chemischen Biologie und
Wirkstoffforschung für Aufgaben von der Identifizierung und Charakterisierung von …

Realising the importance of assessing the quality of the biomolecular structures deposited in
the Protein Data Bank (PDB), the Worldwide Protein Data Bank (wwPDB) partners …

Deciphering the structural effects of gene variants is essential for understanding the
pathophysiological mechanisms of genetic diseases. Using a neurodevelopmental disorder …

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive neoplasms that
commonly occur in patients with neurofibromatosis type 1 (NF1). Effective chemotherapy is …