The eye is a sensory organ exposed to the environment and protected by a mucosal tissue
barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …

Type 2 inflammation is characterized by overexpression and heightened activity of type 2
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …

Somatosensory neurons with cell bodies in the dorsal root ganglia (DRG) project to the skin,
muscles, bones, and viscera to detect touch and temperature as well as to mediate …

Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and
noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory …

Allergic conjunctivitis is a chronic inflammatory disease that is characterized by severe itch
in the conjunctiva, but how neuro-immune interactions shape the pathogenesis of severe …

As a protective mechanism, the cornea is sensitive to noxious stimuli. Here, we show that in
mice, a high proportion of corneal TRPM8+ cold-sensing fibers express the heat-sensitive …

Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch,
but its site of action (sensory neurons vs spinal cord) remains controversial. To determine …

Itch is a unique sensation that helps organisms scratch away external threats; scratching
itself induces an immune response that can contribute to more itchiness. Itch is induced …

Since the last century, advances in healthcare, housing, and education have led to an
increase in life expectancy. Longevity is accompanied by a higher prevalence of age-related …

Infrared (IR) thermographic assessment of ocular surface temperature (OST) is gaining
interest as an adjuvant method to evaluate the ocular surface. It is a quick, non-invasive test …