Boronic acid (and ester) prodrugs targeting the overexpressed level of reactive oxygen
species within tumor microenvironment represent a promising area for the discovery of new …

Increased levels of reactive oxygen species (ROS) have been associated with numerous
pathophysiological conditions including cancer and inflammation and the ROS stimulus …

Breast cancer consists of heterogenic subpopulations, which determine the prognosis and
response to chemotherapy. Among these subpopulations, a very limited number of cancer …

Hydrogen peroxide is the most stable reactive oxygen species generated endogenously,
participating in numerous physiological processes and abnormal pathological conditions …

Proteolysis‐targeting chimeras (PROTACs) provide a powerful technique to degrade
targeted proteins utilizing the cellular ubiquitin‐proteasome system. The major concern is …

We describe several new aromatic nitrogen mustards with various aromatic substituents and
boronic esters that can be activated with H2O2 to efficiently cross-link DNA. In vitro studies …

This study describes the synthesis of arylboronate-based ROS-responsive prodrugs of
doxorubicin and their biological evaluation as anticancer agents. The determination of the …

Arylboronic acid/esters and phenyl selenides-based quinone methide (QM) precursors were
reported to induce DNA interstrand crosslink (ICL) formation upon reaction with the …

A platform has been developed to enable standardization of light sources, allowing
consistent scale‐up from high‐throughput screening in batch to flow, using the same pseudo …

ortho-Quinone methides (o-QMs) underwent formal [4+ 2]-cycloaddition reactions with
arylallenes regioselectively at the styrenyl olefin to furnish the corresponding 3-methylene-2 …