Small silencing RNAs: an expanding universe

M Ghildiyal, PD Zamore - Nature reviews genetics, 2009 - nature.com
Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA
classes have been identified, including microRNAs (miRNAs), small interfering RNAs …

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design

O Terenius, A Papanicolaou, JS Garbutt… - Journal of insect …, 2011 - Elsevier
Gene silencing through RNA interference (RNAi) has revolutionized the study of gene
function, particularly in non-model insects. However, in Lepidoptera (moths and butterflies) …

Towards the elements of successful insect RNAi

JG Scott, K Michel, LC Bartholomay… - Journal of insect …, 2013 - Elsevier
RNA interference (RNAi), the sequence-specific suppression of gene expression, offers
great opportunities for insect science, especially to analyze gene function, manage pest …

Mechanisms of dsRNA uptake in insects and potential of RNAi for pest control: a review

H Huvenne, G Smagghe - Journal of insect physiology, 2010 - Elsevier
RNA interference already proved its usefulness in functional genomic research on insects,
but it also has considerable potential for the control of pest insects. For this purpose, the …

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

G Dietzl, D Chen, F Schnorrer, KC Su, Y Barinova… - Nature, 2007 - nature.com
Forward genetic screens in model organisms have provided important insights into
numerous aspects of development, physiology and pathology. With the availability of …

Mechanisms of gene silencing by double-stranded RNA

G Meister, T Tuschl - Nature, 2004 - nature.com
Double-stranded RNA (dsRNA) is an important regulator of gene expression in many
eukaryotes. It triggers different types of gene silencing that are collectively referred to as …

Ingested double-stranded RNAs can act as species-specific insecticides

S Whyard, AD Singh, S Wong - Insect biochemistry and molecular biology, 2009 - Elsevier
A serious shortcoming of many insecticides is that they can kill non-target species. To
address this issue, we harnessed the sequence specificity of RNA interference (RNAi) to …

Illuminating the silence: understanding the structure and function of small RNAs

TM Rana - Nature reviews Molecular cell biology, 2007 - nature.com
RNA interference (RNAi) is triggered by double-stranded RNA helices that have been
introduced exogenously into cells as small interfering (si) RNAs or that have been produced …

Perspective: machines for RNAi

Y Tomari, PD Zamore - Genes & development, 2005 - genesdev.cshlp.org
RNA silencing pathways convert the sequence information in long RNA, typically double-
stranded RNA, into∼ 21-nt RNA signaling molecules such as small interfering RNAs …

The small RNA profile during Drosophila melanogaster development

AA Aravin, M Lagos-Quintana, A Yalcin, M Zavolan… - Developmental cell, 2003 - cell.com
Small RNAs ranging in size between 20 and 30 nucleotides are involved in different types of
regulation of gene expression including mRNA degradation, translational repression, and …