Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

Connexins are widely distributed proteins in the body that are crucially important for heart
and brain functions. Six connexin subunits form a connexon or hemichannel in the plasma …

Situated between the circulation and the brain, the blood–brain barrier (BBB) protects the
brain from circulating toxins while securing a specialized environment for neuro-glial …

In the brain, astrocytes represent the cellular population that expresses the highest amount
of connexins (Cxs). This family of membrane proteins is the molecular constituent of gap …

Connexin hemichannels (connexons) are building blocks of gap junctions but also function
as free unapposed channels, which has become an active field of research. Defining …

Over the past several decades a large amount of data have established that glial cells, the
main cell population in the brain, dynamically interact with neurons and thus impact their …

Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute
and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury …

It has long been held that electrical excitation spreads from cell-to-cell in the heart via low
resistance gap junctions (GJ). However, it has also been proposed that myocytes could …

Gap junctions are specialized cell-to-cell contacts that allow the direct transfer of small
molecules between cells. A single gap junction channel consists of two hemichannels, or …