The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Availability of the amino acid methionine shows remarkable effects on the physiology of
individual cells and whole organisms. For example, most cancer cells, but not normal cells …

Microbial pathogens deploy effector proteins to manipulate host cell innate immunity, often
using poorly understood unconventional secretion routes. Transfer RNA (tRNA) anticodon …

With global warming and climate change, breeding crop plants tolerant to high-temperature
stress is of immense significance. tRNA 2-thiolation is a highly conserved form of tRNA …

The General Amino Acid Control is a conserved response to amino acid starvation involving
activation of protein kinase Gcn2, which phosphorylates eukaryotic initiation factor 2 (eIF2α) …

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

Caloric restriction (CR) is known to extend life span across species; however, the molecular
mechanisms are not well understood. We investigate the mechanism by which glucose …

Analyses of gene expression of subsurface bacteria and archaea provide insights into their
physiological adaptations to in situ subsurface conditions. We examined patterns of …

In this study, we present an extensive analysis of a widespread group of bacterial tRNA de-
modifying enzymes, dubbed RudS, which consist of a TudS desulfidase fused to a Domain …

Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like
protein 13 (PfK13). Quiescence, a key aspect of resistance, may also be regulated by a yet …