Malignant tumor has become one of the major diseases that seriously endangers human
health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely …

Stem cells are undifferentiated cells that have the unique ability to self-renew and
differentiate into many different cell types. Their function is controlled by core gene networks …

Combinational cancer therapy offers a promising strategy to overcome the limitations of
single-drug treatment, including limited therapeutic efficacy, serious side effects, and low …

Highlights•New drug discovery and molecules in clinical development against cancer stem
cells.•Surface marker, transcription factors and signal transduction pathways in CSCs.•RNAi …

Accumulating evidence has recognized that cancer-associated fibroblasts (CAFs) are major
players in the desmoplastic stroma of ovarian cancer, modulating tumor progression and …

Objectives Homeobox genes are a group of conserved class of transcription factors that
function as key regulators during the embryonic developmental processes. They act as …

Cancer research seeks to understand the biology underlying the progression to malignant
transformation. Recently, the incidence of esophageal adenocarcinoma (EAC) has …

DNA methylation plays important roles in prostate cancer (PCa) development and
progression. African American men have higher incidence and mortality rates of PCa than …

Abstract Background Prospero homeobox 1 (PROX1) functions as a tumor suppressor gene
or an oncogene in various cancer types. However, the distinct function of PROX1 in gastric …

Modulation of the immune system by cancer protective food bioactives has preventive and
therapeutic importance in prostate cancer, but the mechanisms remain largely unclear. The …