The homoeostatic regulation of metabolism is highly complex and involves multiple inputs
from both the nervous and endocrine systems. The gut is the largest endocrine organ in our …

Although ghrelin has been demonstrated to stimulate energy intake and storage through a
central mechanism, its effect on hepatic lipid metabolism remains largely uncharacterized …

Ghrelin, produced mainly by gastric X/A-like cells, triggers a hunger signal to the central
nervous system to stimulate appetite. It remains unclear whether X/A-like cells sense gastric …

Objective Exercise training has several well-established health benefits, including many
related to body weight, appetite control, and blood glucose homeostasis. However, the …

The aim of this study was to characterize the mechanism by which peripheral nesfatin-1
regulates hepatic lipid metabolism. Continuous peripheral infusion of nesfatin-1 reduced …

Background: Ghrelin, a unique 28 amino acid peptide hormone secreted by the gastric X/A
like cells, is an endogenous ligand of the growth hormone secretagogue receptor (GHSR) …

Hepatic steatosis renders liver more vulnerable to ischemia/reperfusion injury (IRI), which
commonly occurs in transplantation, trauma, and liver resection. The underlying mechanism …

Ghrelin plays a neuroprotective role in the process of dopaminergic (DAergic) neurons
degeneration in Parkinson's disease (PD). However, it still largely unknown whether ghrelin …

Ghrelin is an important orexigenic hormone that regulates feeding, metabolism and glucose
homeostasis in human and rodents. Ghrelin functions by binding to its receptor, the growth …

Aims/hypothesis Glucagon-like peptide (GLP-1), an intestinal incretin produced in L cells
through proglucagon processing, is released in response to meal intake. The intracellular …