VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is
overexpressed in many types of tumors and associated with a poor prognosis. Chromatin …

Distal hereditary neuropathies and neuro motor diseases are complex neurological
phenotypes associated with pathogenic variants in a large number of genes, but in some the …

Synthetic lethality is a genetic interaction that results in cell death when two genetic
deficiencies co-occur but not when either deficiency occurs alone, which can be co-opted for …

The accessibility of DNA to different cellular functions requires a dynamic regulation of
chromatin organization that is mediated by different epigenetic modifications, which regulate …

A key role of chromatin kinases is to phosphorylate histone tails during mitosis to
spatiotemporally regulate cell division. Vaccinia-related kinase 1 (VRK1) is a serine …

Dynamic chromatin remodeling requires regulatory mechanisms for its adaptation to
different nuclear function, which are likely to be mediated by signaling proteins. In this …

Simple Summary Dynamic remodeling of chromatin requires epigenetic modifications of
histones. DNA damage induced by doxorubicin causes an increase in histone H4K16ac, a …

Background Dynamic chromatin remodeling is associated with changes in the epigenetic
pattern of histone acetylations and methylations required for processes based on dynamic …

The regulation of histone epigenetic modifications mediates the adaptation of chromatin to
different biological processes. DNA damage causes a local relaxation of chromatin …

DNA damage causes a local distortion of chromatin that triggers the sequential processes
that participate in specific DNA repair mechanisms. This initiation of the repair response …