Neurodegenerative and neurodevelopmental diseases and the gut-brain axis: The potential of therapeutic targeting of the microbiome

B Bicknell, A Liebert, T Borody, G Herkes… - International journal of …, 2023 - mdpi.com
The human gut microbiome contains the largest number of bacteria in the body and has the
potential to greatly influence metabolism, not only locally but also systemically. There is an …

Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

YY Ma, X Li, JT Yu, YJ Wang - Translational Neurodegeneration, 2024 - Springer
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease
(AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's …

[HTML][HTML] Novel therapeutic effects of rifaximin in combination with methylprednisolone for LPS-induced‎ oxidative stress and inflammation in mice‎:‎ An in vivo study

M Salih, AR Abu-Raghif, HA Fawzi - Toxicology reports, 2024 - Elsevier
Cytokine-releasing syndrome (CRS) is a special form of‎‎ systemic inflammatory response
syndrome provoked by‎ factors‎ like viral infections and certain immunomodulatory drugs.‎ To …

The blood-brain barrier, a Key Bridge to treat neurodegenerative diseases

Z Hang, L Zhou, C Xing, Y Wen, H Du - Ageing Research Reviews, 2023 - Elsevier
As a highly selective and semi-permeable barrier that separates the circulating blood from
the brain and central nervous system (CNS), the blood-brain barrier (BBB) plays a critical …

Berberine alleviates ETEC-induced intestinal inflammation and oxidative stress damage by optimizing intestinal microbial composition in a weaned piglet model

Y Wang, Z Zhang, M Du, X Ji, X Liu, C Zhao… - Frontiers in …, 2024 - frontiersin.org
Introduction Enterotoxigenic Escherichia coli (ETEC) is the main diarrhea-causing pathogen
in children and young animals and has become a global health concern. Berberine is a type …

Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: Role of microbiota-gut-brain axis

Q Zhao, Y Hao, X Yang, J Mao, F Tian, Y Gao… - Journal of hazardous …, 2023 - Elsevier
It is established that gut microbiota dysbiosis is implicated in arsenic (As)-induced
neurotoxic process, however, the underlying mode of action remains largely unclear. Here …

The gut-brain axis in parkinson's disease

B Bonaz - Revue Neurologique, 2024 - Elsevier
There is a bi-directional communication between the gut, including the microbiota, and the
brain through the autonomic nervous system. Accumulating evidence has suggested a …

[HTML][HTML] The Role of Microbial Metabolites in the Progression of Neurodegenerative Diseases—Therapeutic Approaches: A Comprehensive Review

J Missiego-Beltrán, AI Beltrán-Velasco - International Journal of …, 2024 - mdpi.com
The objective of this review is to provide a comprehensive examination of the role of
microbial metabolites in the progression of neurodegenerative diseases, as well as to …

A neutral polysaccharide from Persicaria hydropiper (L.) Spach ameliorates lipopolysaccharide-induced intestinal barrier injury via regulating the gut microbiota and …

X Cheng, Y Zhu, J Huang, Y Li, X Jiang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Persicaria hydropiper (L.) Spach, a herb that is prevalent
across Asia and Europe, finds utility as both a culinary ingredient and medicinal herb. In …

Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and …

YC Liu, SY Chen, YY Chen, HY Chang… - International Journal of …, 2024 - Elsevier
Patients may find it challenging to accept several FDA-approved drugs for Alzheimer's
disease (AD) treatment due to their unaffordable prices and side effects. Despite the known …