Towards a unified open access dataset of molecular interactions
Abstract The International Molecular Exchange (IMEx) Consortium provides scientists with a
single body of experimentally verified protein interactions curated in rich contextual detail to …
single body of experimentally verified protein interactions curated in rich contextual detail to …
A reference map of the human binary protein interactome
Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …
understanding of the interactome networks that mediate genotype–phenotype relationships …
A proteome-scale map of the SARS-CoV-2–human contactome
Understanding the mechanisms of coronavirus disease 2019 (COVID-19) disease severity
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …
to efficiently design therapies for emerging virus variants remains an urgent challenge of the …
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation
Structural resolution of protein interactions enables mechanistic and functional studies as
well as interpretation of disease variants. However, structural data is still missing for most …
well as interpretation of disease variants. However, structural data is still missing for most …
FDX1 regulates cellular protein lipoylation through direct binding to LIAS
Ferredoxins are a family of iron–sulfur (Fe-S) cluster proteins that serve as essential electron
donors in numerous cellular processes that are conserved through evolution. The …
donors in numerous cellular processes that are conserved through evolution. The …
Protein-fragment complementation assays for large-scale analysis of protein–protein interactions
E Blaszczak, N Lazarewicz, A Sudevan… - Biochemical Society …, 2021 - portlandpress.com
Protein–protein interactions (PPIs) orchestrate nearly all biological processes. They are also
considered attractive drug targets for treating many human diseases, including cancers and …
considered attractive drug targets for treating many human diseases, including cancers and …
The protein interactome of the citrus Huanglongbing pathogen Candidatus Liberibacter asiaticus
Abstract The bacterium Candidatus Liberibacter asiaticus (CLas) causes citrus
Huanglongbing disease. Our understanding of the pathogenicity and biology of this …
Huanglongbing disease. Our understanding of the pathogenicity and biology of this …
[HTML][HTML] Next-generation large-scale binary protein interaction network for Drosophila melanogaster
Generating reference maps of interactome networks illuminates genetic studies by providing
a protein-centric approach to finding new components of existing pathways, complexes, and …
a protein-centric approach to finding new components of existing pathways, complexes, and …
Drugging the undruggable proteins in cancer: A systems biology approach
In recent years, the research community has, with comprehensive systems biology
approaches and related technologies, gained insight into the vast complexity of numerous …
approaches and related technologies, gained insight into the vast complexity of numerous …
AI-guided pipeline for protein–protein interaction drug discovery identifies a SARS-CoV-2 inhibitor
Protein–protein interactions (PPIs) offer great opportunities to expand the druggable
proteome and therapeutically tackle various diseases, but remain challenging targets for …
proteome and therapeutically tackle various diseases, but remain challenging targets for …