Cytokines play a critical role in coordinating and amplifying a host immune response to
infection. The normal pattern of localized and systemic release of proinflammatory and anti …

BACKGROUND Sepsis and septic shock are severe inflammatory conditions related to high
morbidity and mortality. We performed a systematic review with meta-analysis of randomized …

Background The optimal dosing of antibiotics in critically ill patients receiving renal
replacement therapy (RRT) remains unclear. In this study, we describe the variability in RRT …

In 1977 Peter Kramer performed the first CAVH (continuous arteriovenous hemofiltration)
treatment in Gottingen, Germany. CAVH soon became a reliable alternative to hemo-or …

Coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome
(ARDS) is associated with high mortality. Lung-protective ventilation is the current standard …

Sepsis is the leading cause of acute kidney injury (AKI) in the intensive care unit. As the
most common treatment of septic AKI, it is believed that continuous renal replacement …

Continuous renal replacement therapy (CRRT) is intended to function continuously and is
prescribed for this outcome. Anticoagulants may not always be used. Clotting and clogging …

Objectives: Continuous renal replacement therapy becomes available utilization for pediatric
critically ill, but the impact of mortality rate in severe sepsis remains no consistent …

Sepsis is a life-threatening syndrome initiated by a dysregulated host response to infection.
Maladaptive inflammatory burst damages host tissues and causes organ dysfunction, the …

Dr. Bellomo has received grants and consultancy and speaking fees from BBraun and
Baxter. Dr. Ronco has received consultancy and speaking fees from ASAHI, Astute …