Introduction: Compounds incorporating guanidine moiety have found many practical
applications in diverse areas of chemistry, such as nucleophilic organocatalysis, anion …

RNA interference (RNAi) was discovered as a cellular defense mechanism more than
decade ago. It has been exploited as a powerful tool for genetic manipulation. Characterized …

The development of cardiovascular pathologies is partly attributed to epigenetic causes,
including histone methylation, which appears to be an important marker in hearts that …

The Jumonji-containing domain protein, KDM4C, is a histone demethylase associated with
the development of several forms of human cancer. However, its specific function in the …

Epigenetic changes induced by environmental factors are increasingly relevant in
cardiovascular diseases. The most frequent molecular component in cardiac hypertrophy is …

Epigenetic changes induced by histone demethylases play an important role in
differentiation and pathological changes in cardiac cells. However, the role of the jumonji …

Histone lysine specific demethylase 1 (LSD1) is overexpressed in diverse hematologic
disorders and recognized as a promising target for blood medicines. In this study, molecular …

Targeting the genetic material without destruction is a priority to develop safe anticancer
drugs. Histone deacetylase 8 (HDAC8), which is proved to be involved in carcinogenesis, is …

US9790195B2 - KDM1A inhibitors for the treatment of disease - Google Patents
US9790195B2 - KDM1A inhibitors for the treatment of disease - Google Patents KDM1A …

The balance between acetylation and deacetylation of histone proteins plays a critical role in
the regulation of genomic functions. Aberrations in global levels of histone modifications are …