Scientific and clinical progress together with the development of effective novel therapeutic
options has engendered multiple important changes in the diagnosis and management of …

Angioedema is an acute swelling of the deeper layers of the skin or mucosa resulting from a
transient increase in vascular permeability. Angioedema can occur in the absence or …

Hereditary Angioedema (HAE) is a rare and disabling disease for which early diagnosis and
effective therapy are critical. This revision and update of the global WAO/EAACI guideline on …

Hereditary Angioedema (HAE) is a rare and disabling disease. Early diagnosis and
appropriate therapy are essential. This update and revision of the global guideline for HAE …

Background Hereditary angioedema (HAE) is a rare genetic disease usually caused by
mutation in the C1 inhibitor or the coagulation Factor XII gene. However, in a series of …

Background Guidelines recommend effective on-demand therapy for all individuals with
hereditary angioedema. We aimed to assess the novel oral plasma kallikrein inhibitor …

Background The consensus documents published to date on hereditary angioedema with
C1 inhibitor deficiency (C1‐INH‐HAE) have focused on adult patients. Many of the previous …

Abstract Background Bradykinin-mediated angioedema (Bk-AE) can be life-threatening and
requires specific targeted therapies. Knowledge of its epidemiology may help optimize its …

Background Hereditary angioedema with normal C1‐INH may be linked to specific
mutations in the coagulation factor 12 (FXII) gene (HAE‐FXII) or mutations in genes that are …

Background Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) causes
swelling in the skin and upper airways and pain in the abdomen because of mucosal …