Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Severe AKI is often associated with multiorgan dysfunction, but the mechanisms of this
remote tissue injury are unknown. We hypothesized that renal necroinflammation releases …

Acute kidney injury (AKI) is common in critically ill patients and is associated with increased
morbidity and mortality. Dysfunction of other organs is an important cause of poor outcomes …

Acute kidney injury (AKI) has emerged as a major public health problem that affects millions
of patients worldwide and leads to decreased survival and increased progression of …

Physical trauma can affect any individual and is globally accountable for more than one in
every ten deaths. Although direct severe kidney trauma is relatively infrequent, extrarenal …

Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity.
Inflammation is now believed to play a major role in the pathopathophysiology of AKI. It is …

Tissue injury can drive secondary organ injury; however, mechanisms and mediators are not
well understood. To identify interorgan cross-talk mediators, we used acute kidney injury …

Acute kidney injury (AKI) is a common complication in critically ill patients and subsequently
worsens outcomes. Although many drugs to prevent and treat AKI have shown benefits in …

Despite the availability of renal replacement therapy, acute kidney injury (AKI) is associated
with high mortality and morbidity. In humans, it is difficult to determine whether AKI is a …