Extensive research on the Ras proteins and their functions in cell physiology over the past
30 years has led to numerous insights that have revealed the involvement of Ras not only in …

Protein kinase C (PKC) isoforms comprise a family of lipid-activated enzymes that have
been implicated in a wide range of cellular functions. PKCs are modular enzymes comprised …

Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …

Mitogen-activated protein (MAP) kinases, also known as extracellular signal-regulated
kinases (ERKs), are thought to act at an integration point for multiple biochemical signals …

The functions and biochemical mechanisms involved in cell signalling by phosphoinositide
breakdown are now well defined[l-3]. drolysis of polyphosphoinositides (PI) yieI motes rhe …

Oncogenes were first described as retrovirus-encoded genes that produced tumors in birds
and rodents. These genes were then shown to be dominant mutated forms of host genes …

A substantial number of novel guanine nucleotide binding regulatory proteins have been
identified over the last few years but the function of many of them is largely unknown. This …

Several mechanisms of agonist control of PC hydrolysis have been described: control by G
proteins, protein kinase C, Ca2+, and tyrosine kinases. The relative importance of these …

The search for proteins which interact with the active GTP-bound form of Ras in order to
transmit signals for proliferation, differentiation and oncogenesis has been a long one. Now …

We have studied the post‐translational processing of p21ras proteins. The primary
translation product pro‐p21 is cytosolic and is rapidly converted to a cytosolic form (c‐p21) …