Intervertebral disc (IVD) degeneration is a common finding on spine imaging that increases
in prevalence with age. IVD degeneration is a frequent cause of low back pain, which is a …

Low back pain is a very common symptom. It occurs in high-income, middle-income, and low-
income countries and all age groups from children to the elderly population. Globally, years …

Degenerative disc disease is a leading cause of chronic back pain in the aging population in
the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with …

Discogenic back pain is multifactorial; hence, physicians often struggle to identify the
underlying source of the pain. As a result, discogenic back pain is often hard to treat—even …

Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …

Spinal pain is a major clinical problem, however, its origins and underlying mechanisms
remain unclear. Here we report that in mice, osteoclasts induce sensory innervation in the …

Abstract Purpose of Review The endplates form the interface between the rigid vertebral
bodies and compliant intervertebral discs. Proper endplate function involves a balance …

Intervertebral disc degeneration (IVDD) has been known as a highly prevalent and disabling
disease, which is one of the main causes of low back pain and disability. Unfortunately …

Study design Cross-sectional cohort analysis of patients with Modic Changes (MC).
Objective Our goal was to characterize the molecular and cellular features of MC bone …

Abstract Background Context Prolonged microgravity exposure is associated with localized
low back pain and an elevated risk of post-flight disc herniation. Although the mechanisms …