Exosomes, a class of extracellular vesicles of endocytic origin, play a critical role in
paracrine signaling for successful cell-cell crosstalk in vivo. However, limitations in our …

Fibroblasts are crucial components of the skin structure. They were traditionally believed to
maintain the skin's structure by producing extracellular matrix and other elements. Recent …

Tissue nanotransfection (TNT), a cutting-edge technique of in vivo gene therapy, has gained
substantial attention in various applications ranging from in vivo tissue reprogramming in …

Construction of in vitro vascular models is of great significance to various biomedical
research, such as pharmacokinetics and hemodynamics, and thus is an important direction …

Objective: Hydrolyzed collagen-based matrices are widely used as wound care dressings.
Information on the mechanism of action of such dressings is scanty. The objective of this …

Organ fibrosis causes collagen fiber overgrowth and impairs organ function. Cardiac fibrosis
after myocardial infarction impairs cardiac function significantly, pulmonary fibrosis reduces …

Human death marks the end of organismal life under conditions such that the components of
the human body continue to be alive. Such postmortem cellular survival depends on the …

Fetal skin achieves scarless wound repair. Dermal fibroblasts play a central role in
extracellular matrix deposition and scarring outcomes. Both fetal and gingival wound repair …

Chronic wounds pose a significant challenge to healthcare. Stemming from impaired wound
healing, the consequences can be severe, ranging from amputation to mortality. This …

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are two emerging
research technologies that uniquely characterize gene expression microenvironments on a …