A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …

This review describes the Hierarchical Taxonomy of Psychopathology (HiTOP) model of
psychosis-related psychopathology, the psychosis superspectrum. The HiTOP psychosis …

Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with …

Background Schizophrenia and bipolar disorder share genetic liability, and some structural
brain abnormalities are common to both conditions. First-degree relatives of patients with …

Offspring of parents with severe mental illness, including schizophrenia, bipolar disorder,
and major depressive disorder, have a one-in-three risk of developing severe mental illness …

Brain size and IQ are positively correlated. However, multiple meta-analyses have led to
considerable differences in summary effect estimations, thus failing to provide a plausible …

Abstract Language-related symptoms, such as disorganized, impoverished speech and
communicative behaviors, are one of the core features of schizophrenia. These features …

First‐degree relatives of patients diagnosed with schizophrenia (SZ‐FDRs) show similar
patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect …

Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric disorders that share
clinical features and several risk genes. Important information about their genetic …

Objective We conducted a multimodal coordinate-based meta-analysis (CBMA) to
investigate structural and functional brain alterations in first-degree relatives of …