The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Abstract 'Jack of all trades, master of everything'is a fair label for transforming growth factor
β1 (TGF-β)–a cytokine that controls our life at many levels. In the adult organism, TGF-β1 is …

Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and
continuously undergoes controlled remodelling. This process involves quantitative and …

The bioavailability of members of the transforming growth factor β (TGF-β) family is
controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s
to account for the non-lethal phenotypes of mice with inactivated genes encoding …

Background: Endothelial-to-mesenchymal transition (EndMT) has been identified as a
critical driver of vascular inflammation and atherosclerosis, and TGF-β (transforming growth …

With the increased awareness about the importance of the composition, organization, and
stiffness of the extracellular matrix (ECM) for tissue homeostasis, there is a renewed need to …